Modelling and imaging cardiac repolarization abnormalities
نویسندگان
چکیده
منابع مشابه
Modelling and imaging cardiac repolarization abnormalities.
Repolarization abnormalities, including those induced by the congenital or acquired long QT (LQT) syndrome, provide a substrate for life-threatening cardiac arrhythmias. In this article, we use computational biology to link HERG mutations mechanistically to the resulting abnormalities of the whole-cell action potential. We study how the kinetic properties of I(Ks) (the slow delayed rectifier) t...
متن کاملModelling the molecular basis of cardiac repolarization.
AIMS To study the properties of ion-channel gating (I(Ks), the slow delayed rectifier K+ channel) that underlie the channel's participation in rate-dependent repolarization of the cardiac action potential (AP). METHODS Computational biology approach was used to simulate the channel gating and the AP of a mammalian ventricular myocyte. RESULTS At fast rate, channels accumulate at closed stat...
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Early repolarization pattern (ERP) may not be the entirely benign condition it was initially thought to be. In a recent metaanalysis, it was associated with increased risk and low to intermediate absolute incidence rate of arrhythmia death (1). However, the vast majority of subjects with ERP will never experience any malignant arrhythmia during their lifetime, and therefore, ability to identify...
متن کاملCardiac repolarization: insights from mathematical modeling and electrocardiographic imaging (ECGI).
Cardiac repolarization is a complex rate dependent process. At the cellular level, it depends on a delicate dynamic balance of ion channel currents. At the heart level, it is spatially heterogeneous, leading to spatial gradients of potential and excitability. This article provides insights into the molecular mechanisms of the delayed rectifiers I(Kr) (rapid) and I(Ks) (slow) that underlie effec...
متن کاملRepolarization abnormalities in heart failure.
See article by Lacroix et al. [1] (pages 42 –50) in this et al. deals with both a triggering mechanism and a issue. substrate of arrhythmogenesis in heart failure: The hypothThe paper by Lacroix et al., published in this issue of eses that inspired the investigation are that (1) the Cardiovascular Research, is of interest because it deals prolongation of the action potential duration known to w...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2006
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.2005.01586.x